Dr. Madhuri Manpadi's Undergraduate Research

Project I - Synthesis of novel 1,2 and 1,4 naphthoquinone analogues using microwave methodology and their novel biological evaluation

We developed a microwave-assisted method for the synthesis of new aromatic and alkyl enamines of 1,2 and 1,4 naphthoquinones. The reaction is done in 45 seconds and pure product is isolated in moderate to high yields. The compounds will be screened for anticancer activity using MTT assay. We found some compounds that showed promising cytotoxic activity at low micromolar concentrations. Based on the preliminary data we are developing new compounds and evaluating their activity against various cancer cell lines.

Project II – Development of a Et3B mediated radical methodology for the synthesis of allenes

Allene is an intrinsically chiral molecule that is one of the most underused functional groups in organic synthesis.  We are working on developing a green trithylborane mediated radical reaction for the synthesis of allenes. Unlike the organocuprate reactions that are done under anhydrous and inert conditions, these reactions can be done in a vial open to the atmosphere.  Efforts are underway to study the addition of both electrophilic and nucleophilic radicals to propargyl epoxides.