The department of music is housed in the Mabee Center for the Performing Arts. Clara Thompson Hall of Music contains a large classroom, eight teaching studios and fifteen practice rooms, including one with a Conn electronic organ. Clara Thompson Auditorium, with a seating capacity of 450, is known for its superb acoustics, and houses a French-style Peter Tkach harpsichord built in 1984, and a Steinway concert grand piano.

The O'Bannon Music Center, opened in 1979, contains the music office, four teaching studios, one small classroom, and two instrumental rehearsal rooms which also are equipped as classrooms. Located in the lower level is the Garton Electronic Music Studio, a MIDI-based computer music and ear training lab which utilizes the notation software, Sibelius, and ear training software, MacGAMUT.

The Lydy Center, renovated for the expansion of the department in 2004, contains choral and instrumental rehearsal rooms, an intimate recital space, a large classroom and a faculty lounge.

Congregational Hall houses the 6,183 square-foot Drury University Center for Music Therapy and Wellness, an on-campus music therapy clinic. Outstanding features of this clinic include both large and small activity rooms with adjoining observation rooms. The clinic serves a growing number and variety of clients both on and off campus including children with autism and learning disabilities, assisted living residents, palliative care, and persons with behavioral health needs.

The department also maintains and uses the "Chalfant" pipe organ in Stone Chapel, named after William Chalfant, Director of the Drury Conservatory of Music at the turn of the twentieth century. It was constructed in 1906 by Lyon and Healy of Chicago. This three manual instrument with approximately 1,400 pipes was substantially renovated between 1990 and 1998.